Human TIRAP protein (Recombinant) (N-His) (STJP004995)

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STJP004995
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TIRAP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TIRAP
Gene ID: 114609
Uniprot ID: TIRAP_HUMAN
Immunogen Region: Met1-Ser221
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
Function Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6).
Protein Name Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein
Tir Domain-Containing Adapter Protein
Adaptor Protein Wyatt
Myd88 Adapter-Like Protein
Myd88-2
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Cellular Localisation Cytoplasm
Cell Membrane
Membrane
Colocalizes With Dab2ip At The Plasma Membrane
Alternative Protein Names Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein protein
Tir Domain-Containing Adapter Protein protein
Adaptor Protein Wyatt protein
Myd88 Adapter-Like Protein protein
Myd88-2 protein
TIRAP protein
MAL protein

Information sourced from Uniprot.org

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