Human TIPIN protein (Recombinant) (His-Tag) (STJP018445)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TIPIN-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TIPIN |
| Gene ID | 54962 |
| Uniprot ID | TIPIN_HUMAN |
| Accession Number | NP_060328 |
| Immunogen | Human |
| Immunogen Region | 1-301aa |
| Immunogen Sequence |
Additional Info
| Function | Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. |
| Protein Name | Timeless-Interacting Protein |
| Database Links | Reactome: R-HSA-5693607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Timeless-Interacting Protein proteinTIPIN protein |
Information sourced from Uniprot.org