Human TIAF1 protein (Recombinant) (His-Tag) (STJP017817)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TIAF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYO18AUniprot ID=TIAF1_HUMAN" |
| Accession Number | NP_004731 |
| Immunogen | Human |
| Immunogen Region | 1-115aa |
| Immunogen Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSS PSSPFREQSF LCAAGDAGEE SRVQVLKNEV RRGSPVLLGW VEQAYADKCV CGPSAPPAPT PPSLSQRVMC NDLFKVNPFQ LQQFRADPST ASLLLCPGGL DHKLNLRGKA WG |
Additional Info
| Tissue Specificity | Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. |
| Function | Isoform TIAF1: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. |
| Protein Name | Putative Tgfb1-Induced Anti-Apoptotic Factor 112 Kda Tgf-Beta-1-Induced Antiapoptotic Factor |
| Cellular Localisation | Isoform Tiaf1: Nucleus |
| Alternative Protein Names | Putative Tgfb1-Induced Anti-Apoptotic Factor 1 protein12 Kda Tgf-Beta-1-Induced Antiapoptotic Factor proteinMYO18A proteinTIAF1 protein |
Information sourced from Uniprot.org