Human TGFBR3 protein (Recombinant) (N-His) (STJP015913)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TGFBR3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | TGFBR3 |
| Gene ID | 7049 |
| Uniprot ID | TGBR3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser36-Glu360 |
Additional Info
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. |
| Protein Name | Transforming Growth Factor Beta Receptor Type 3Tgf-Beta Receptor Type 3Tgfr-3BetaglycanTransforming Growth Factor Beta Receptor IiiTgf-Beta Receptor Type Iii |
| Database Links | Reactome: R-HSA-1502540Reactome: R-HSA-190370Reactome: R-HSA-190373Reactome: R-HSA-201451Reactome: R-HSA-2173789Reactome: R-HSA-9839383Reactome: R-HSA-9839389Reactome: R-HSA-9839394Reactome: R-HSA-9839397Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceExtracellular MatrixExists Both As A Membrane-Bound Form And As Soluble Form In Serum And In The Extracellular Matrix |
| Alternative Protein Names | Transforming Growth Factor Beta Receptor Type 3 proteinTgf-Beta Receptor Type 3 proteinTgfr-3 proteinBetaglycan proteinTransforming Growth Factor Beta Receptor Iii proteinTgf-Beta Receptor Type Iii proteinTGFBR3 protein |
Information sourced from Uniprot.org