Human TGFBR2/TGFR-2 protein (Recombinant) (N-GST & C-His) (STJP008474)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TGFBR2/TGFR-2-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TGFBR2 |
| Gene ID | 7048 |
| Uniprot ID | TGFR2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln49-Glu151 |
Additional Info
| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform 1: Has transforming growth factor beta-activated receptor activity. Isoform 2: Has transforming growth factor beta-activated receptor activity. Isoform 3: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. |
| Protein Name | Tgf-Beta Receptor Type-2Tgfr-2Tgf-Beta Type Ii ReceptorTransforming Growth Factor-Beta Receptor Type IiTgf-Beta Receptor Type IiTbetar-Ii |
| Database Links | Reactome: R-HSA-2173788Reactome: R-HSA-2173789Reactome: R-HSA-2173791Reactome: R-HSA-3304356Reactome: R-HSA-3642279Reactome: R-HSA-3645790Reactome: R-HSA-3656532Reactome: R-HSA-3656535Reactome: R-HSA-5689603Reactome: R-HSA-9839389 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform 3: Secreted |
| Alternative Protein Names | Tgf-Beta Receptor Type-2 proteinTgfr-2 proteinTgf-Beta Type Ii Receptor proteinTransforming Growth Factor-Beta Receptor Type Ii proteinTgf-Beta Receptor Type Ii proteinTbetar-Ii proteinTGFBR2 protein |
Information sourced from Uniprot.org