Function | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. |
Protein Name | Alpha-Globin Transcription Factor Cp2Saa3 Enhancer FactorTranscription Factor Lsf |
Cellular Localisation | Nucleus |
Alternative Protein Names | Alpha-Globin Transcription Factor Cp2 proteinSaa3 Enhancer Factor proteinTranscription Factor Lsf proteinTFCP2 proteinLSF proteinSEF protein |
Information sourced from Uniprot.org