| Post Translational Modifications | Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. |
| Function | Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. |
| Protein Name | Inactive Serine/Threonine-Protein Kinase Tex14Protein Kinase-Like Protein Sgk307Sugen Kinase 307Testis-Expressed Sequence 14Testis-Expressed Sequence 14 Protein |
| Cellular Localisation | CytoplasmMidbodyChromosomeCentromereKinetochoreDetected In The Intercellular Bridges That Connect Male Germ Cell Daughter Cells After Cell Division |
| Alternative Protein Names | Inactive Serine/Threonine-Protein Kinase Tex14 proteinProtein Kinase-Like Protein Sgk307 proteinSugen Kinase 307 proteinTestis-Expressed Sequence 14 proteinTestis-Expressed Sequence 14 Protein proteinTEX14 proteinSGK307 protein |
Information sourced from Uniprot.org
