| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TERF1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TERF1 |
| Gene ID: | 7013 |
| Uniprot ID: | TERF1_HUMAN |
| Immunogen Region: | Arg94-Ser253 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. |
| Function | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. |
| Protein Name | Telomeric Repeat-Binding Factor 1Nima-Interacting Protein 2Ttaggg Repeat-Binding Factor 1Telomeric Protein Pin2/Trf1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleChromosomeTelomereColocalizes With Telomeric Dna In Interphase And Prophase CellsTelomeric Localization Decreases In MetaphaseAnaphase And TelophaseAssociates With The Mitotic SpindleColocalizes With Triobp Isoform 1 At The Telomeres In Interphase |
| Alternative Protein Names | Telomeric Repeat-Binding Factor 1 proteinNima-Interacting Protein 2 proteinTtaggg Repeat-Binding Factor 1 proteinTelomeric Protein Pin2/Trf1 proteinTERF1 proteinPIN2 proteinTRBF1 proteinTRF proteinTRF1 protein |
Information sourced from Uniprot.org
