Human TCOF1 protein (Recombinant) (N-GST & C-His) (STJP008458)

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STJP008458
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TCOF1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TCOF1
Gene ID: 6949
Uniprot ID: TCOF_HUMAN
Immunogen Region: Ala2-Arg77
Immunogen: Homo sapiens (Human)
Function Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Protein Name Treacle Protein
Treacher Collins Syndrome Protein
Cellular Localisation Nucleus
Nucleolus
Alternative Protein Names Treacle Protein protein
Treacher Collins Syndrome Protein protein
TCOF1 protein

Information sourced from Uniprot.org

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