| Function | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. |
| Protein Name | Tbc1 Domain Family Member 23Hcv Non-Structural Protein 4a-Transactivated Protein 1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleLocalization To The Trans-Golgi Is Regulated By Arl1 And Arl5b/Arl8Arl1 Increases Golgi LocalizationWhile Arl5b Decreases ItRecruitment To The Trans-Golgi Network Requires The Presence Of Golga1 And Golga4But Not That Of Fam91a1Recruited On Ap-1-Derived Vesicles By Wdr11 Complex |
| Alternative Protein Names | Tbc1 Domain Family Member 23 proteinHcv Non-Structural Protein 4a-Transactivated Protein 1 proteinTBC1D23 proteinNS4ATP1 protein |
Information sourced from Uniprot.org
