Tissue Specificity | Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. |
Post Translational Modifications | N-glycosylated. |
Function | Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR. May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation. May play a role in sperm tail differentiation and motility and hence male fertility. |
Protein Name | Testis Anion Transporter 1Anion Exchange TransporterSolute Carrier Family 26 Member 8 |
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Cellular Localisation | MembraneMulti-Pass Membrane ProteinLocated At Both The Annulus And The Equatorial Segment Of The Human Sperm Head |
Alternative ELISA Names | Testis Anion Transporter 1 ELISA kitAnion Exchange Transporter ELISA kitSolute Carrier Family 26 Member 8 ELISA kitSLC26A8 ELISA kitTAT1 ELISA kit |
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Information sourced from Uniprot.org