| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CD96 |
| Gene ID: | 10225 |
| Uniprot ID: | TACT_HUMAN |
| Immunogen: | Recombinant Human TACTILE/CD96 (C110S) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val22-Met503) of Human TACTILE/CD96 (C110S) (Accession #P40200-2) fused with a C-His tag at the C-terminus. |
| Immunogen Region: | Val22-Met503 |
| Immunogen Sequence: | VWEKTVNTEENVYATLGSDV NLTCQTQTVGFFVQMQWSKV TNKIDLIAVYHPQYGFYCAY GRPCESLVTFTETPENGSKW TLHLRNMSSSVSGRYECMLV LYPEGIQTKIYNLLIQTHVT ADEWNSNHTIEIEINQTLEI PCFQNSSSKISSEFTYAWSV EDNGTQETLISQNHLISNST LLKDRVKLGTDYRLHLSPVQ IFDDGRKFSCHIRVGPNKIL RSSTTVKVFAKPEIPVIVE |
| Tissue Specificity | Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells. |
| Function | May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. |
| Protein Name | T-Cell Surface Protein TactileCell Surface Antigen Cd96T Cell-Activated Increased Late Expression ProteinCd Antigen Cd96 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | T-Cell Surface Protein Tactile proteinCell Surface Antigen Cd96 proteinT Cell-Activated Increased Late Expression Protein proteinCd Antigen Cd96 proteinCD96 protein |
Information sourced from Uniprot.org
