| Post Translational Modifications | Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
| Protein Name | Synaptotagmin-Like Protein 2Breast Cancer-Associated Antigen Sga-72mExophilin-4 |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Isoform 1: CytoplasmCell MembraneRecruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27aIsoform 4: Cell MembraneIn The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior RegionsLocalizes On The Glucagon Granules In The Cell Periphery |
| Alternative Protein Names | Synaptotagmin-Like Protein 2 proteinBreast Cancer-Associated Antigen Sga-72m proteinExophilin-4 proteinSYTL2 proteinKIAA1597 proteinSGA72M proteinSLP2 proteinSLP2A protein |
Information sourced from Uniprot.org
