Human SYNGAP1 protein (Recombinant) (N-His) (STJP009995)

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STJP009995
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SYNGAP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SYNGAP1
Gene ID: 8831
Uniprot ID: SYGP1_HUMAN
Immunogen Region: Gly443-Asn635
Immunogen: Homo sapiens (Human)
Function Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
Protein Name Ras/Rap Gtpase-Activating Protein Syngap
Neuronal Rasgap
Synaptic Ras Gtpase-Activating Protein 1
Synaptic Ras-Gap 1
Database Links Reactome: R-HSA-5658442
Alternative Protein Names Ras/Rap Gtpase-Activating Protein Syngap protein
Neuronal Rasgap protein
Synaptic Ras Gtpase-Activating Protein 1 protein
Synaptic Ras-Gap 1 protein
SYNGAP1 protein
KIAA1938 protein

Information sourced from Uniprot.org

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