| Post Translational Modifications | The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. |
| Function | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes.SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis.a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. |
| Protein Name | Nesprin-1EnaptinKash Domain-Containing Protein 1Kash1Myocyte Nuclear Envelope Protein 1Myne-1Nuclear Envelope Spectrin Repeat Protein 1Synaptic Nuclear Envelope Protein 1Syne-1 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | Nucleus Outer MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideNucleusNucleus EnvelopeCytoplasmCytoskeletonMyofibrilSarcomereThe Largest Part Of The Protein Is CytoplasmicWhile Its C-Terminal Part Is Associated With The Nuclear EnvelopeMost Probably The Outer Nuclear MembraneIn Skeletal And Smooth MusclesA Significant Amount Is Found In The SarcomeresIn MyoblastsRelocalized From The Nuclear Envelope To The Nucleus And Cytoplasm During Cell DifferentiationIsoform Gsrp-56: Golgi Apparatus |
| Alternative Protein Names | Nesprin-1 proteinEnaptin proteinKash Domain-Containing Protein 1 proteinKash1 proteinMyocyte Nuclear Envelope Protein 1 proteinMyne-1 proteinNuclear Envelope Spectrin Repeat Protein 1 proteinSynaptic Nuclear Envelope Protein 1 proteinSyne-1 proteinSYNE1 proteinC6orf98 proteinKIAA0796 proteinKIAA1262 proteinKIAA1756 proteinMYNE1 protein |
Information sourced from Uniprot.org
