| Post Translational Modifications | ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from chromatin. |
| Function | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). |
| Protein Name | Fact Complex Subunit Spt16Chromatin-Specific Transcription Elongation Factor 140 Kda SubunitFact 140 Kda SubunitFactp140Facilitates Chromatin Transcription Complex Subunit Spt16Hspt16 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6804756Reactome: R-HSA-75955 |
| Cellular Localisation | NucleusChromosomeColocalizes With Rna Polymerase Ii On ChromatinRecruited To Actively Transcribed Loci |
| Alternative Protein Names | Fact Complex Subunit Spt16 proteinChromatin-Specific Transcription Elongation Factor 140 Kda Subunit proteinFact 140 Kda Subunit proteinFactp140 proteinFacilitates Chromatin Transcription Complex Subunit Spt16 proteinHspt16 proteinSUPT16H proteinFACT140 proteinFACTP140 protein |
Information sourced from Uniprot.org
