| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SUMO1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SUMO1 |
| Gene ID: | 7341 |
| Uniprot ID: | SUMO1_HUMAN |
| Immunogen Region: | Met1-Val101 |
| Immunogen: | Homo sapiens (Human) |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1.this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. |
| Protein Name | Small Ubiquitin-Related Modifier 1Sumo-1Gap-Modifying Protein 1Gmp1Smt3 Homolog 3SentrinUbiquitin-Homology Domain Protein Pic1Ubiquitin-Like Protein Smt3cSmt3cUbiquitin-Like Protein Ubl1 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678Reactome: R-HSA-3065679Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-3232142Reactome: R-HSA-3899300Reactome: R-HSA-4085377Reactome: R-HSA-4090294Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-4655427Reactome: R-HSA-4755510Reactome: R-HSA-5693565Reactome: R-HSA-5696395Reactome: R-HSA-877312Reactome: R-HSA-8866904Reactome: R-HSA-9615933Reactome: R-HSA-9683610Reactome: R-HSA-9694631Reactome: R-HSA-9793242Reactome: R-HSA-9833482 |
| Cellular Localisation | Nucleus MembraneNucleus SpeckleCytoplasmNucleusPml BodyCell MembraneRecruited By Bcl11a Into The Nuclear BodyIn The Presence Of Zfhx3Sequesterd To Nuclear Body (Nb)-Like Dots In The Nucleus Some Of Which Overlap Or Closely Associate With Pml Body |
| Alternative Protein Names | Small Ubiquitin-Related Modifier 1 proteinSumo-1 proteinGap-Modifying Protein 1 proteinGmp1 proteinSmt3 Homolog 3 proteinSentrin proteinUbiquitin-Homology Domain Protein Pic1 proteinUbiquitin-Like Protein Smt3c proteinSmt3c proteinUbiquitin-Like Protein Ubl1 proteinSUMO1 proteinSMT3C proteinSMT3H3 proteinUBL1 proteinOK proteinSW-cl.43 protein |
Information sourced from Uniprot.org