| Post Translational Modifications | The N-terminus is blocked. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols. |
| Protein Name | Sulfotransferase 2a1St2a1Bile Salt SulfotransferaseDehydroepiandrosterone SulfotransferaseDhea-StDhea-St8Hydroxysteroid SulfotransferaseHstSt2Sult2a3 |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-1989781Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Sulfotransferase 2a1 proteinSt2a1 proteinBile Salt Sulfotransferase proteinDehydroepiandrosterone Sulfotransferase proteinDhea-St proteinDhea-St8 proteinHydroxysteroid Sulfotransferase proteinHst proteinSt2 proteinSult2a3 proteinSULT2A1 proteinHST proteinSTD protein |
Information sourced from Uniprot.org
