Human SULT1E1 protein (Recombinant) (N-His) (STJP007444)

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STJP007444
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SULT1E1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SULT1E1
Gene ID: 6783
Uniprot ID: ST1E1_HUMAN
Immunogen Region: Met1-Ile294
Immunogen: Homo sapiens (Human)
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Protein Name Sulfotransferase 1e1
St1e1
Est-1
Estrogen Sulfotransferase
Sulfotransferase - Estrogen-Preferring
Database Links Reactome: R-HSA-156584
Reactome: R-HSA-9753281
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Sulfotransferase 1e1 protein
St1e1 protein
Est-1 protein
Estrogen Sulfotransferase protein
Sulfotransferase - Estrogen-Preferring protein
SULT1E1 protein
STE protein

Information sourced from Uniprot.org

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