Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. |
Protein Name | Sulfotransferase 1c2St1c2Sulfotransferase 1c1Sult1c#1Humsultc2 |
Database Links | Reactome: R-HSA-156584 |
Cellular Localisation | CytoplasmLysosome |
Alternative Protein Names | Sulfotransferase 1c2 proteinSt1c2 proteinSulfotransferase 1c1 proteinSult1c#1 proteinHumsultc2 proteinSULT1C2 proteinSULT1C1 protein |
Information sourced from Uniprot.org