| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds. Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol. Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration. Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. |
| Protein Name | Sulfotransferase 1c2St1c2Sulfotransferase 1c1Sult1c#1Humsultc2 |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | CytoplasmLysosomeMitochondrion |
| Alternative Protein Names | Sulfotransferase 1c2 proteinSt1c2 proteinSulfotransferase 1c1 proteinSult1c#1 proteinHumsultc2 proteinSULT1C2 proteinSULT1C1 protein |
Information sourced from Uniprot.org