| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human STXBP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | STXBP1 |
| Gene ID: | 6812 |
| Uniprot ID: | STXB1_HUMAN |
| Immunogen Region: | Met1-Ser594 |
| Immunogen: | Homo sapiens (Human) |
| Function | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions. |
| Protein Name | Syntaxin-Binding Protein 1Munc18-1N-Sec1Protein Unc-18 Homolog 1Unc18-1Protein Unc-18 Homolog AUnc-18aP67 |
| Database Links | Reactome: R-HSA-181429 P61764-1Reactome: R-HSA-181430 P61764-1Reactome: R-HSA-210500 P61764-1Reactome: R-HSA-212676 P61764-1Reactome: R-HSA-264642 P61764-1Reactome: R-HSA-422356Reactome: R-HSA-6794361Reactome: R-HSA-888590 P61764-1 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Protein Names | Syntaxin-Binding Protein 1 proteinMunc18-1 proteinN-Sec1 proteinProtein Unc-18 Homolog 1 proteinUnc18-1 proteinProtein Unc-18 Homolog A proteinUnc-18a proteinP67 proteinSTXBP1 proteinUNC18A protein |
Information sourced from Uniprot.org
