| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human STX1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | STX1A |
| Gene ID: | 6804 |
| Uniprot ID: | STX1A_HUMAN |
| Immunogen Region: | Met1-Val255 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis. |
| Function | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1). |
| Protein Name | Syntaxin-1aNeuron-Specific Antigen Hpc-1 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642Reactome: R-HSA-264876Reactome: R-HSA-422356Reactome: R-HSA-449836Reactome: R-HSA-5250971Reactome: R-HSA-5682910Reactome: R-HSA-6794361Reactome: R-HSA-888590Reactome: R-HSA-9609523Reactome: R-HSA-9662360 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Iv Membrane ProteinSynapseSynaptosomeCell MembraneColocalizes With Kcnb1 At The Cell MembraneIsoform 2: Secreted |
| Alternative Protein Names | Syntaxin-1a proteinNeuron-Specific Antigen Hpc-1 proteinSTX1A proteinSTX1 protein |
Information sourced from Uniprot.org