| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant human Transferrin at 2 Mu g/mL (100 Mu L/well) can bind Recombinant human TfR with a linear range of 4-17 ng/mL. |
| Gene Symbol: |
TFRC |
| Gene ID: |
7037 |
| Uniprot ID: |
TFR1_HUMAN |
| Immunogen Region: |
Cys89-Phe760 |
| Immunogen: |
Recombinant Human sTfR/CD71 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys89-Phe760) of human sTfR (Accession #NP_001121620.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
CKGVEPKTECERLAGTESPV REEPGEDFPAARRLYWDDLK RKLSEKLDSTDFTGTIKLLN ENSYVPREAGSQKDENLALY VENQFREFKLSKVWRDQHFV KIQVKDSAQNSVIIVDKNGR LVYLVENPGGYVAYSKAATV TGKLVHANFGTKKDFEDLYT PVNGSIVIVRAGKITFAEKV ANAESLNAIGVLIYMDQTKF PIVNAELSFFGHAHLGTGDP YTPGFPSFNHTQFPPSRSS |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Protein Name | Transferrin Receptor Protein 1TrTfrTfr1TrfrT9P90Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum FormStfr |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-917977Reactome: R-HSA-9696270Reactome: R-HSA-9696273Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTransferrin Receptor Protein 1Serum Form: Secreted |
| Alternative Protein Names | Transferrin Receptor Protein 1 proteinTr proteinTfr proteinTfr1 proteinTrfr proteinT9 proteinP90 proteinCd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form proteinStfr proteinTFRC protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
