| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human sTfR/CD71-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant human Transferrin at 2 Mu g/mL (100 Mu L/well) can bind Recombinant human TfR with a linear range of 4-17 ng/mL. |
| Gene Symbol: |
TFRC |
| Gene ID: |
7037 |
| Uniprot ID: |
TFR1_HUMAN |
| Immunogen Region: |
Cys89-Phe760 |
| Immunogen: |
Recombinant Human sTfR/CD71 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys89-Phe760) of human sTfR (Accession #NP_001121620.1) fused with a 6×His tag at the C-terminus. |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Protein Name | Transferrin Receptor Protein 1TrTfrTfr1TrfrT9P90Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum FormStfr |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-917977Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTransferrin Receptor Protein 1Serum Form: Secreted |
| Alternative Protein Names | Transferrin Receptor Protein 1 proteinTr proteinTfr proteinTfr1 proteinTrfr proteinT9 proteinP90 proteinCd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form proteinStfr proteinTFRC protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
