Human STAMBP protein (Recombinant) (N-His) (STJP003438)

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STJP003438
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human STAMBP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: STAMBP
Gene ID: 10617
Uniprot ID: STABP_HUMAN
Immunogen Region: Lys126-Ser368
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Function Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Protein Name Stam-Binding Protein
Associated Molecule With The Sh3 Domain Of Stam
Endosome-Associated Ubiquitin Isopeptidase
Database Links Reactome: R-HSA-5689901
Cellular Localisation Nucleus
Membrane
Peripheral Membrane Protein
Cytoplasm
Early Endosome
Alternative Protein Names Stam-Binding Protein protein
Associated Molecule With The Sh3 Domain Of Stam protein
Endosome-Associated Ubiquitin Isopeptidase protein
STAMBP protein
AMSH protein

Information sourced from Uniprot.org

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