Human ST6GALNAC6/Sialyltransferase 7F protein (Recombinant) (N-His) (STJP005824)

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STJP005824
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ST6GALNAC6/Sialyltransferase 7F-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ST6GALNAC6
Gene ID: 30815
Uniprot ID: SIA7F_HUMAN
Immunogen Region: Val67-Thr333
Immunogen: Homo sapiens (Human)
Function Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
Protein Name Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 6
Galnac Alpha-2 -6-Sialyltransferase Vi
St6galnac Vi
St6galnacvi
Hst6galnac Vi
Sialyltransferase 7f
Siat7-F
Database Links Reactome: R-HSA-4085001
Reactome: R-HSA-9037629
Reactome: R-HSA-9840309
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 6 protein
Galnac Alpha-2 -6-Sialyltransferase Vi protein
St6galnac Vi protein
St6galnacvi protein
Hst6galnac Vi protein
Sialyltransferase 7f protein
Siat7-F protein
ST6GALNAC6 protein
SIAT7F protein
UNQ708 protein
PRO1359 protein

Information sourced from Uniprot.org

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