| Function | Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST. Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules. Plays a role in axon outgrowth and branching. Required for cell division. |
| Protein Name | Microtubule Nucleation Factor Ssna1Nuclear Autoantigen Of 14 KdaSjoegren Syndrome Nuclear Autoantigen 1 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleMidbodyFlagellum Basal BodyFlagellum AxonemeCell ProjectionAxonIn SpermStrongly Expressed In The Basal Body Region With Weaker Expression In The AxonemeLocalizes To Axon Branching Points In Neurons |
| Alternative Protein Names | Microtubule Nucleation Factor Ssna1 proteinNuclear Autoantigen Of 14 Kda proteinSjoegren Syndrome Nuclear Autoantigen 1 proteinSSNA1 proteinNA14 protein |
Information sourced from Uniprot.org
