| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SRSF7-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SRSF7 |
| Gene ID: | 6432 |
| Uniprot ID: | SRSF7_HUMAN |
| Immunogen Region: | Ser2-Thr83 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Extensively phosphorylated on serine residues in the RS domain. |
| Function | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 7Splicing Factor 9g8Splicing Factor - Arginine/Serine-Rich 7 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Serine/Arginine-Rich Splicing Factor 7 proteinSplicing Factor 9g8 proteinSplicing Factor - Arginine/Serine-Rich 7 proteinSRSF7 proteinSFRS7 protein |
Information sourced from Uniprot.org