| Function | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. |
| Protein Name | Slit-Robo Rho Gtpase-Activating Protein 2Srgap2Formin-Binding Protein 2Rho Gtpase-Activating Protein 34 |
| Database Links | Reactome: R-HSA-428543Reactome: R-HSA-5663220Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013406Reactome: R-HSA-9013420Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Cell MembraneCell ProjectionDendritic SpinePostsynaptic DensityPostsynaptic Cell MembraneLamellipodiumCytoplasmic VesiclePhagosomeNucleusCytoplasmCytosolRecruited To Actin-Rich Phagosomes During PhagocytosisTranslocates From Nucleus To Cytoplasm During Development |
| Alternative Protein Names | Slit-Robo Rho Gtpase-Activating Protein 2 proteinSrgap2 proteinFormin-Binding Protein 2 proteinRho Gtpase-Activating Protein 34 proteinSRGAP2 proteinARHGAP34 proteinFNBP2 proteinKIAA0456 proteinSRGAP2A protein |
Information sourced from Uniprot.org
