| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SRF-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SRF |
| Gene ID: | 6722 |
| Uniprot ID: | SRF_HUMAN |
| Immunogen Region: | Thr231-Gln474 |
| Immunogen: | Homo sapiens (Human) |
| Function | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. |
| Protein Name | Serum Response FactorSrf |
| Database Links | Reactome: R-HSA-5663220Reactome: R-HSA-9031628Reactome: R-HSA-9634638Reactome: R-HSA-9733709Reactome: R-HSA-9768777 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Serum Response Factor proteinSrf proteinSRF protein |
Information sourced from Uniprot.org
