Human SPRY2 protein (Recombinant) (N-His) (STJP003285)

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STJP003285
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SPRY2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SPRY2
Gene ID: 10253
Uniprot ID: SPY2_HUMAN
Immunogen Region: Ser116-Thr305
Immunogen: Homo sapiens (Human)
Function Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination.
Protein Name Protein Sprouty Homolog 2
Spry-2
Database Links Reactome: R-HSA-1295596
Reactome: R-HSA-182971
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Ruffle Membrane
Associated With Microtubules In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor)
Alternative Protein Names Protein Sprouty Homolog 2 protein
Spry-2 protein
SPRY2 protein

Information sourced from Uniprot.org

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