Human SPIN1 protein (Recombinant) (N-His) (STJP006288)

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STJP006288
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SPIN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SPIN1
Gene ID: 10927
Uniprot ID: SPIN1_HUMAN
Immunogen Region: Met1-Ser262
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated during oocyte meiotic maturation.
Function Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Protein Name Spindlin-1
Ovarian Cancer-Related Protein
Spindlin1
Cellular Localisation Nucleus
Nucleolus
Alternative Protein Names Spindlin-1 protein
Ovarian Cancer-Related Protein protein
Spindlin1 protein
SPIN1 protein
OCR protein
SPIN protein

Information sourced from Uniprot.org

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