| Post Translational Modifications | Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. |
| Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. |
| Protein Name | Nuclear Body Protein Sp140Lymphoid-Restricted Homolog Of Sp100Lysp100Nuclear Autoantigen Sp-140Speckled 140 Kda |
| Cellular Localisation | NucleusPml BodyCytoplasmLocalized To Nuclear Structures Termed LandsFor Lysp100-Associated Nuclear DomainsLands Are GlobularElectron-Dense Structures Most Often Found In The NucleoplasmBut Also Found At The Nuclear Membrane And In The CytoplasmSuggesting That These Structures May Traffic Between The Cytoplasm And The NucleusAlso Colocalizes With Pml In A Subset Of Pml Nuclear Bodies |
| Alternative Protein Names | Nuclear Body Protein Sp140 proteinLymphoid-Restricted Homolog Of Sp100 proteinLysp100 proteinNuclear Autoantigen Sp-140 proteinSpeckled 140 Kda proteinSP140 proteinLYSP100 protein |
Information sourced from Uniprot.org
