| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SOX10-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SOX10 |
| Gene ID: | 6663 |
| Uniprot ID: | SOX10_HUMAN |
| Immunogen Region: | Lys67-Asp170 |
| Immunogen: | Homo sapiens (Human) |
| Function | Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. |
| Protein Name | Transcription Factor Sox-10 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9764302Reactome: R-HSA-9824585Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Transcription Factor Sox-10 proteinSOX10 protein |
Information sourced from Uniprot.org