| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor. |
| Protein Name | Sorbitol DehydrogenaseSdh(R -R-Butanediol DehydrogenaseL-Iditol 2-DehydrogenasePolyol DehydrogenaseRibitol DehydrogenaseRdhXylitol DehydrogenaseXdh |
| Database Links | Reactome: R-HSA-5652227Reactome: R-HSA-5661270 |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinCell ProjectionCiliumFlagellumAssociated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The FlagellumAlso Found In The EpididymosomeSecreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface |
| Alternative Protein Names | Sorbitol Dehydrogenase proteinSdh protein(R -R-Butanediol Dehydrogenase proteinL-Iditol 2-Dehydrogenase proteinPolyol Dehydrogenase proteinRibitol Dehydrogenase proteinRdh proteinXylitol Dehydrogenase proteinXdh proteinSORD protein |
Information sourced from Uniprot.org
