| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Sorcin/SRI-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 40% Glycerol, 0.2M NaCl, 1mM DTT, 0.1mM PMSF |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRI |
| Gene ID: | 6717 |
| Uniprot ID: | SORCN_HUMAN |
| Immunogen Region: | 1-198aa |
| Accession Number: | NP_003121 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAYPGHP GAGGGYYPGG YGGAPGGPAF PGQTQDPLYG YFAAVAGQDG QIDADELQRC LTQSGIAGGY KPFNLETCRL MVSMLDRDMS GTMGFNEFKE LWAVLNGWRQ HFISFDTDRS GTVDPQELQK ALTTMGFRLS PQAVNSIAKR YSTNGKITFD DYIACCVKLR ALTDSFRRRD TAQQGVVNFP YDDFIQCVMS V |
| Tissue Specificity | Detected in cardiac myocytes. |
| Function | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| Protein Name | Sorcin22 Kda ProteinCp-22Cp22V19 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-5578775Reactome: R-HSA-936837 |
| Cellular Localisation | CytoplasmSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideRelocates To The Sarcoplasmic Reticulum Membrane In Response To Elevated Calcium Levels |
| Alternative Protein Names | Sorcin protein22 Kda Protein proteinCp-22 proteinCp22 proteinV19 proteinSRI protein |
Information sourced from Uniprot.org