Human SORBS2 protein (Recombinant) (N-His) (STJP009585)

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STJP009585
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SORBS2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SORBS2
Gene ID: 8470
Uniprot ID: SRBS2_HUMAN
Immunogen Region: Lys865-Thr1001
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by CBL. Dephosphorylated by PTPN12.
Function Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Protein Name Sorbin And Sh3 Domain-Containing Protein 2
Arg-Binding Protein 2
Argbp2
Arg/Abl-Interacting Protein 2
Sorbin
Cellular Localisation Cytoplasm
Perinuclear Region
Apical Cell Membrane
Cell Junction
Focal Adhesion
Cell Projection
Lamellipodium
Found At The Z-Disk Sarcomeres
Stress Fibers
Dense Bodies And Focal Adhesion
In Pancreatic Acinar Cells
Localized Preferentially To The Apical Membrane
Colocalized With Vinculin And Filamentous Actin At Focal Adhesions And Lamellipodia Of Pancreatic Cells
Alternative Protein Names Sorbin And Sh3 Domain-Containing Protein 2 protein
Arg-Binding Protein 2 protein
Argbp2 protein
Arg/Abl-Interacting Protein 2 protein
Sorbin protein
SORBS2 protein
ARGBP2 protein
KIAA0777 protein

Information sourced from Uniprot.org

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