Human SOD1/Cu-Zn SOD protein (Recombinant) (No-Tag) (STJP019783)

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STJP019783
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Short Description :Recombinant-Human SOD1/Cu-Zn SOD-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Specific activity is > 500unit/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25C.
Gene Symbol:SOD1
Gene ID:6647
Uniprot ID:SODC_HUMAN
Accession Number:NP_000445.1
Immunogen:Human
Immunogen Region:1-154aa
Immunogen Sequence:MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI GIAQ
Post Translational Modifications Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation. The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required. Palmitoylation helps nuclear targeting and decreases catalytic activity. Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Protein Name Superoxide Dismutase Cu-Zn
Superoxide Dismutase 1
Hsod1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-3299685
Reactome: R-HSA-8950505
Cellular Localisation Cytoplasm
Nucleus
Predominantly Cytoplasmic
The Pathogenic Variants Als1 Arg-86 And Ala-94 Gradually Aggregates And Accumulates In Mitochondria
Alternative Protein Names Superoxide Dismutase Cu-Zn protein
Superoxide Dismutase 1 protein
Hsod1 protein
SOD1 protein

Information sourced from Uniprot.org

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