Tissue Specificity | Expressed in male germ cells of adult testis (at protein level). |
Post Translational Modifications | Phosphorylated by CSNK1D/CK1. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability. |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. |
Protein Name | Snare-Associated Protein SnapinBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7Bloc-1 Subunit 7Synaptosomal-Associated Protein 25-Binding ProteinSnap-Associated Protein |
Database Links | Reactome: R-HSA-432722 |
Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolPerinuclear RegionGolgi Apparatus MembraneLysosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneColocalizes With Nanos1 And Pum2 In The Perinuclear Region Of Germ Cells |
Alternative ELISA Names | Snare-Associated Protein Snapin ELISA kitBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 ELISA kitBloc-1 Subunit 7 ELISA kitSynaptosomal-Associated Protein 25-Binding Protein ELISA kitSnap-Associated Protein ELISA kitSNAPIN ELISA kitBLOC1S7 ELISA kitSNAP25BP ELISA kitSNAPAP ELISA kit |
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Information sourced from Uniprot.org