| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SNAP25-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SNAP25 |
| Gene ID: | 6616 |
| Uniprot ID: | SNP25_HUMAN |
| Immunogen Region: | Met1-Gly206 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C) which hydrolyzes the 198-Arg-|-Ala-199 bond and inhibits neurotransmitter release. C.botulinum type C only rarely infects humans. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release. |
| Function | t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. |
| Protein Name | Synaptosomal-Associated Protein 25Snap-25Super ProteinSupSynaptosomal-Associated 25 Kda Protein |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642Reactome: R-HSA-422356Reactome: R-HSA-449836Reactome: R-HSA-5250968Reactome: R-HSA-5250971Reactome: R-HSA-5250992Reactome: R-HSA-6798695Reactome: R-HSA-888590Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneLipid-AnchorSynapseSynaptosomePhotoreceptor Inner SegmentMembrane Association Requires PalmitoylationExpressed Throughout CytoplasmConcentrating At The Perinuclear RegionColocalizes With Kcnb1 At The Cell MembraneColocalizes With Plcl1 At The Cell Membrane |
| Alternative Protein Names | Synaptosomal-Associated Protein 25 proteinSnap-25 proteinSuper Protein proteinSup proteinSynaptosomal-Associated 25 Kda Protein proteinSNAP25 proteinSNAP protein |
Information sourced from Uniprot.org