Human SMUG1 (Single Strand Selective Monofunctional Uracil DNA Glycosylase 1) Sandwich ELISA Kit Kit (STJE0012242)

Human SMUG1 (Single Strand Selective Monofunctional Uracil DNA Glycosylase 1) Sandwich ELISA Kit Kit (STJE0012242)

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STJE0012242
£465.50 - £636.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.047ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This SMUG1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SMUG1
Gene ID: 23583
Uniprot ID: SMUG1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU) in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Protein Name Single-Strand Selective Monofunctional Uracil Dna Glycosylase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110357
Cellular Localisation Nucleus
Alternative ELISA Names Single-Strand Selective Monofunctional Uracil Dna Glycosylase ELISA kit
SMUG1 ELISA kit
output

Information sourced from Uniprot.org

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