| Function | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 4Smc Protein 4Smc-4Chromosome-Associated Polypeptide CHcap-CXcap-C Homolog |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-2514853 |
| Cellular Localisation | NucleusCytoplasmChromosomeIn Interphase CellsThe Majority Of The Condensin Complex Is Found In The CytoplasmWhile A Minority Of The Complex Is Associated With ChromatinA Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase CellsDuring MitosisMost Of The Condensin Complex Is Associated With The ChromatinAt The Onset Of ProphaseThe Regulatory Subunits Of The Complex Are Phosphorylated By Cdc2Leading To Condensin's Association With Chromosome Arms And To Chromosome CondensationDissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Protein Names | Structural Maintenance Of Chromosomes Protein 4 proteinSmc Protein 4 proteinSmc-4 proteinChromosome-Associated Polypeptide C proteinHcap-C proteinXcap-C Homolog proteinSMC4 proteinCAPC proteinSMC4L1 protein |
Information sourced from Uniprot.org
