Human SMC3 protein (Recombinant) (N-His) (STJP006224)

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STJP006224
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SMC3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SMC3
Gene ID: 9126
Uniprot ID: SMC3_HUMAN
Immunogen Region: Glu995-Glu1181
Immunogen: Homo sapiens (Human)
Function Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Protein Name Structural Maintenance Of Chromosomes Protein 3
Smc Protein 3
Smc-3
Basement Membrane-Associated Chondroitin Proteoglycan
Bamacan
Chondroitin Sulfate Proteoglycan 6
Chromosome-Associated Polypeptide
Hcap
Database Links Reactome: R-HSA-1221632
Reactome: R-HSA-2467813
Reactome: R-HSA-2468052
Reactome: R-HSA-2470946
Reactome: R-HSA-2500257
Reactome: R-HSA-3108214
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Chromosome
Centromere
Associates With Chromatin
Before Prophase It Is Scattered Along Chromosome Arms
During Prophase
Most Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk
Except At Centromeres
Where Cohesin Complexes Remain
At Anaphase
The Rad21 Subunit Of The Cohesin Complex Is Cleaved
Leading To The Dissociation Of The Complex From Chromosomes
Allowing Chromosome Separation
The Phosphorylated Form At Ser-1083 Is Preferentially Associated With Unsynapsed Chromosomal Regions
Alternative Protein Names Structural Maintenance Of Chromosomes Protein 3 protein
Smc Protein 3 protein
Smc-3 protein
Basement Membrane-Associated Chondroitin Proteoglycan protein
Bamacan protein
Chondroitin Sulfate Proteoglycan 6 protein
Chromosome-Associated Polypeptide protein
Hcap protein
SMC3 protein
BAM protein
BMH protein
CSPG6 protein
SMC3L1 protein

Information sourced from Uniprot.org