| Function | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2Samrca2Brg1-Associated Factor 190bBaf190bProbable Global Transcription Activator Snf2l2Protein Brahma HomologHbrmSnf2-Alpha |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusLocalizes To Sites Of Dna Damage |
| Alternative Protein Names | Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2 proteinSamrca2 proteinBrg1-Associated Factor 190b proteinBaf190b proteinProbable Global Transcription Activator Snf2l2 proteinProtein Brahma Homolog proteinHbrm proteinSnf2-Alpha proteinSMARCA2 proteinBAF190B proteinBRM proteinSNF2A proteinSNF2L2 protein |
Information sourced from Uniprot.org
