| Function | Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity. Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells. |
| Protein Name | AntileukoproteinaseAlpBlpiHusi-1Mucus Proteinase InhibitorMpiProtease Inhibitor Wap4Secretory Leukocyte Protease InhibitorSeminal Proteinase InhibitorWap Four-Disulfide Core Domain Protein 4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Antileukoproteinase proteinAlp proteinBlpi proteinHusi-1 proteinMucus Proteinase Inhibitor proteinMpi proteinProtease Inhibitor Wap4 proteinSecretory Leukocyte Protease Inhibitor proteinSeminal Proteinase Inhibitor proteinWap Four-Disulfide Core Domain Protein 4 proteinSLPI proteinWAP4 proteinWFDC4 protein |
Information sourced from Uniprot.org
