Function | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. |
Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf2Nherf-2Nhe3 Kinase A Regulatory Protein E3karpSry-Interacting Protein 1Sip-1Sodium-Hydrogen Exchanger Regulatory Factor 2Solute Carrier Family 9 Isoform A3 Regulatory Factor 2Tyrosine Kinase Activator Protein 1Tka-1 |
Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinNucleusApical Cell MembraneLocalizes With Ezr And Podxl At The Apical Cell Membrane Of Glomerular Epithelium Cells And The Sides Of The Food ProcessesNuclearIn A Punctate Pattern |
Alternative Protein Names | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf2 proteinNherf-2 proteinNhe3 Kinase A Regulatory Protein E3karp proteinSry-Interacting Protein 1 proteinSip-1 proteinSodium-Hydrogen Exchanger Regulatory Factor 2 proteinSolute Carrier Family 9 Isoform A3 Regulatory Factor 2 proteinTyrosine Kinase Activator Protein 1 proteinTka-1 proteinNHERF2 proteinSLC9A3R2 protein |
Information sourced from Uniprot.org