Human SLC9A3R1 protein (Recombinant) (N-His) (STJP010630)

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STJP010630
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC9A3R1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NHERF1
Gene ID: 9368
Uniprot ID: NHRF1_HUMAN
Immunogen Region: Met1-Ala116
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on serine residues.
Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Protein Name Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1
Nherf-1
Ezrin-Radixin-Moesin-Binding Phosphoprotein 50
Ebp50
Regulatory Cofactor Of Na(+/H(+ Exchanger
Sodium-Hydrogen Exchanger Regulatory Factor 1
Solute Carrier Family 9 Isoform A3 Regulatory Factor 1
Cellular Localisation Cytoplasm
Apical Cell Membrane
Endomembrane System
Peripheral Membrane Protein
Cell Projection
Filopodium
Ruffle
Microvillus
Translocates From The Cytoplasm To The Apical Cell Membrane In A Podxl-Dependent Manner
Colocalizes With Cftr At The Midpiece Of Sperm Tail
Colocalizes With Actin In Microvilli-Rich Apical Regions Of The Syncytiotrophoblast
Found In Microvilli
Ruffling Membrane And Filopodia Of Hela Cells
Present In Lipid Rafts Of T-Cells
Alternative Protein Names Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1 protein
Nherf-1 protein
Ezrin-Radixin-Moesin-Binding Phosphoprotein 50 protein
Ebp50 protein
Regulatory Cofactor Of Na(+/H(+ Exchanger protein
Sodium-Hydrogen Exchanger Regulatory Factor 1 protein
Solute Carrier Family 9 Isoform A3 Regulatory Factor 1 protein
NHERF1 protein
NHERF protein
SLC9A3R1 protein

Information sourced from Uniprot.org