| Function | Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity. Required in retinal cells to maintain normal pH which is necessary for normal vision. In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules. |
| Protein Name | Sodium-Driven Chloride Bicarbonate ExchangerSolute Carrier Family 4 Member 10 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell ProjectionDendriteAxonPerikaryonPresynapsePostsynapseDetected In Dendrites And Axon Terminals Of Retinal Off Bipolar Cells And In Axon Terminals Of On Bipolar CellsIn Amacrine CellsLocated In The PerikaryonAlso Detected In Basal And Apical Dendrites Of Hippocampal Pyramidal CellsLocalized To Gabaergic Inhibitory Presynapses |
| Alternative Protein Names | Sodium-Driven Chloride Bicarbonate Exchanger proteinSolute Carrier Family 4 Member 10 proteinSLC4A10 proteinNBCN2 proteinNCBE protein |
Information sourced from Uniprot.org
