| Post Translational Modifications | The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate. Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded. Glycosylated. |
| Function | Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations. |
| Protein Name | Zinc Transporter Zip4Solute Carrier Family 39 Member 4Zrt- And Irt-Like Protein 4Zip-4 |
| Database Links | Reactome: R-HSA-442380Reactome: R-HSA-5619088 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneApical Cell MembraneColocalized With Tfrc In The Recycling EndosomesCycles Between Endosomal Compartments And The Plasma Membrane In Response To Zn(2+) AvailabilityZn(2+) Deficiency Promotes Accumulation Of Slc39a4 On The Surface MembraneWhereas High Extracellular Zn(2+) Levels Induce Internalization Of Slc39a4But Also Trigger Drastic Removal Of Cellular Slc39a4 Via Proteasomal And Lysosomal Degradation Pathways |
| Alternative Protein Names | Zinc Transporter Zip4 proteinSolute Carrier Family 39 Member 4 proteinZrt- And Irt-Like Protein 4 proteinZip-4 proteinSLC39A4 proteinZIP4 protein |
Information sourced from Uniprot.org
