| Function | May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes. Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 5Fatp-5Fatty Acid Transport Protein 5Bile Acid-Coa LigaseBa-Coa LigaseBalBile Acyl-Coa SynthetaseBacsCholate--Coa LigaseFatty-Acid-Coenzyme A Ligase - Very Long-Chain 3Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 5Very Long-Chain Acyl-Coa Synthetase Homolog 2Vlcs-H2Vlcsh2Very Long-Chain Acyl-Coa Synthetase-Related ProteinVlacs-RelatedVlacsr |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-193775 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosomeCell Membrane |
| Alternative Protein Names | Long-Chain Fatty Acid Transport Protein 5 proteinFatp-5 proteinFatty Acid Transport Protein 5 proteinBile Acid-Coa Ligase proteinBa-Coa Ligase proteinBal proteinBile Acyl-Coa Synthetase proteinBacs proteinCholate--Coa Ligase proteinFatty-Acid-Coenzyme A Ligase - Very Long-Chain 3 proteinLong-Chain-Fatty-Acid--Coa Ligase proteinSolute Carrier Family 27 Member 5 proteinVery Long-Chain Acyl-Coa Synthetase Homolog 2 proteinVlcs-H2 proteinVlcsh2 proteinVery Long-Chain Acyl-Coa Synthetase-Related Protein proteinVlacs-Related proteinVlacsr proteinSLC27A5 proteinACSB proteinACSVL6 proteinFACVL3 proteinFATP5 protein |
Information sourced from Uniprot.org
