| Function | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 4Fatp-4Fatty Acid Transport Protein 4Arachidonate--Coa LigaseLong-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 4Very Long-Chain Acyl-Coa Synthetase 4Acsvl4 |
| Database Links | Reactome: R-HSA-5619108Reactome: R-HSA-804914 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Long-Chain Fatty Acid Transport Protein 4 proteinFatp-4 proteinFatty Acid Transport Protein 4 proteinArachidonate--Coa Ligase proteinLong-Chain-Fatty-Acid--Coa Ligase proteinSolute Carrier Family 27 Member 4 proteinVery Long-Chain Acyl-Coa Synthetase 4 proteinAcsvl4 proteinSLC27A4 proteinACSVL4 proteinFATP4 protein |
Information sourced from Uniprot.org
